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Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives

Solasodine 11 is a steroidal alkaloid with various biological activities.Herein,8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro.Significant improvement in antiproliferative activity was achieved among some of the synthetic...

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Bibliographic Details
Published in:Chinese chemical letters 2010-09, Vol.21 (9), p.1087-1090
Main Authors: Zha, Xiao Ming, Zhang, Fei Ran, Shan, Jia Qi, Zhang, Yi Hua, Liu, Jun O., Sun, Hong Bin
Format: Article
Language:English
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Summary:Solasodine 11 is a steroidal alkaloid with various biological activities.Herein,8 novel solasodine derivatives were synthesized and their effect on prostate cancer cell proliferation was assessed in vitro.Significant improvement in antiproliferative activity was achieved among some of the synthetic analogs.In particular,19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line(IC50= 3.91μmol/L).
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.04.020