Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatin

New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance（MDR） reve...

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Bibliographic Details
Published in:Chinese chemical letters 2010, Vol.21 (11), p.1273-1276
Main Author: Jun Chao Shao Zhi Hua Ye Hai Xia Lin Dian Long Wang Na Han
Format: Article
Language:English
Subjects:
ESIMS
NMR
多药耐药
晶体学
环氧丙烷
类似物
紫杉醇
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Summary:New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance（MDR） reversal agents and new synthetic precursors of paclitaxel analogues.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.07.001