Application of N-thiocyanatosuccinimide as a reagent for the facile conversion of epoxides into thiocyanohydrines

The use of in situ generated N-thiocyanatosuccinimide with NH4SCN offers an efficient reagent system for the conversion of epoxides into their corresponding thiocyanohydrines in good to high yields. The major advantages of this method are as follows： use of cheap reagent, high regioselectivity, simp...

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Bibliographic Details
Published in:Chinese chemical letters 2011, Vol.22 (1), p.21-24
Main Author: Babak Mokhtari Roya Azadi Samira Rahmani-Nezhad
Format: Article
Language:English
Subjects:
Epoxide
N-Thiocyanatosuccinimide
Ring opening
Thiocyanohydrin
产量高
区域选择性
可用性
易用性
环氧化物
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Summary:The use of in situ generated N-thiocyanatosuccinimide with NH4SCN offers an efficient reagent system for the conversion of epoxides into their corresponding thiocyanohydrines in good to high yields. The major advantages of this method are as follows： use of cheap reagent, high regioselectivity, simple availability of reagent, ease of workup of the reaction.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.09.004