Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity

A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi. On the basis of spectral evidences, its structure was established and named as 4,5-didemethylpodophyllotoxin 7′- O- β- d-glucopyranoside. This compound showed cytotoxicity against four...

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Bibliographic Details
Published in:Chinese chemical letters 2011-02, Vol.22 (2), p.181-184
Main Authors: Zhao, Chang Qi, Zhu, Yan Yan, Chen, Shu Ying, Ogihara, Yukio
Format: Article
Language:English
Subjects:
4,5-Didemethylpodophyllotoxin 7′- O- β- d-glucopyranoside
Berberidaceae
Cytotoxicity
Sinopodophyllum emodi
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Summary:A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi. On the basis of spectral evidences, its structure was established and named as 4,5-didemethylpodophyllotoxin 7′- O- β- d-glucopyranoside. This compound showed cytotoxicity against four human cancer cell lines (Hela, K562, SH-SY5Y and CNE) in vitro.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.10.013