Design synthesis and biological evaluation of 3-substituted triazole derivatives

Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal agents.Results of pre...

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Bibliographic Details
Published in:Chinese chemical letters 2011-05, Vol.22 (5), p.519-522
Main Authors: Wang, Bao Gang, Yu, Shi Chong, Chai, Xiao Yun, Yan, Yong Zheng, Hu, Hong Gang, Wu, Qiu Ye
Format: Article
Language:English
Subjects:
1,3-Dipolar cycloaddition
Antifungal activity
Synthesis
Triazole
三唑衍生物
二氟苯基
抗真菌药物
活性部位
生物评价
脱甲基
致病真菌
设计合成
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Summary:Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal agents.Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.11.029