Guanidine hydrochloride： An active and simple catalyst for Mannich type reaction in solvent-free condition

Commercially available guanidine hydrochloride （GuHC1） has been found to be a highly efficient catalyst for the Mannich reaction. β-Amino carbonyl compounds were obtained in reasonable yields when the Mannich reaction was carried out at room temperature under solvent-free conditions.

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Bibliographic Details
Published in:Chinese chemical letters 2011-07, Vol.22 (7), p.797-800
Main Authors: Heravi, Majid M., Zakeri, Masoumeh, Mohammadi, Narges
Format: Article
Language:English
Subjects:
ch型
Guanidine hydrochloride
Mannich reaction
Mannich反应
β-Amino-ketones
收益率
无溶剂条件
氨基
盐酸胍
羰基化合物
高效催化剂
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Description
Summary:Commercially available guanidine hydrochloride （GuHC1） has been found to be a highly efficient catalyst for the Mannich reaction. β-Amino carbonyl compounds were obtained in reasonable yields when the Mannich reaction was carried out at room temperature under solvent-free conditions.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.12.046