Ibuprofen induced drug loaded polymeric micelles

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly （N-isopropylacrylalaide）. Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding betwee...

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Bibliographic Details
Published in:Chinese chemical letters 2011-09, Vol.22 (9), p.1123-1126
Main Authors: Tan, Song Wei, Wang, Hong Jun, Tu, Ke Hua, Jiang, Hong Liang, Wang, Li Qun
Format: Article
Language:English
Subjects:
Drug
Hydrogen-bonding
Micelle
Poly (N-isopropylacrylamide)
Thermo-sensitive
动态光散射
布洛芬
异丙基丙烯酰胺
聚合物胶束
药物选择
葡聚糖
载药
透射电子显微镜
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Summary:Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly （N-isopropylacrylalaide）. Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly （N-isopropylacrylamide） and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2011.04.005