A clean and efficient cyclocondensation to pyrido[2,3-d]pyrimidine derivatives in aqueous media

A series of pyrido[2,3-d]pyrimidine derivatives were easily constructed by cyclocondensation reactions of 6-aminouracils or 6- aminothiouracil withα,β-unsaturated carbonyl compounds（aldehyde,ketone and ester） possessing a leaving group on theβposition,in H_2O under reflux conditions.

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Bibliographic Details
Published in:Chinese chemical letters 2011-10, Vol.22 (10), p.1183-1186
Main Authors: Baharfar, Robabeh, Azimi, Razieh
Format: Article
Language:English
Subjects:
6-Aminothiouracil
Diethyl ethoxymethylenemalonate
Pyrido[2,3- d]pyrimidine
α, β-Unsaturated carbonyl compounds
不饱和
吡啶
嘧啶衍生物
基团
水介质
羰基化合物
酯
醛
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Description
Summary:A series of pyrido[2,3-d]pyrimidine derivatives were easily constructed by cyclocondensation reactions of 6-aminouracils or 6- aminothiouracil withα,β-unsaturated carbonyl compounds（aldehyde,ketone and ester） possessing a leaving group on theβposition,in H_2O under reflux conditions.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2011.04.020