Synthesis of oleanolic disaccharide derivatives

Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities.Herein,using association principle of drug design,OA disaccharide 17 was designed a...

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Published in:Chinese chemical letters 2012-04, Vol.23 (4), p.403-406
Main Authors: Pei, Shu Chen, Wu, Jian Bo, Lei, Fan, Qian, Shan, Hai, Li, Wu, Yong
Format: Article
Language:English
Subjects:
Anti-tumor
Arabinopyranosyl
Association principle
C-17
Oleanolic acid
Rhamnopyranosyl
合成
抗肿瘤活性
生物活性
药物设计
衍生物
鼠李糖
齐墩果酸
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description Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities.Herein,using association principle of drug design,OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-（1→2）-a-L-arabinopyranosyl disaccharide moiety,which has proved to be a unique sugar sequence with strongly antitumor activity,and modified OA with a nitrile at C-17.
doi_str_mv 10.1016/j.cclet.2012.01.022
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ispartof Chinese chemical letters, 2012-04, Vol.23 (4), p.403-406
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subjects Anti-tumor
Arabinopyranosyl
Association principle
C-17
Oleanolic acid
Rhamnopyranosyl
合成
抗肿瘤活性
生物活性
药物设计
衍生物
鼠李糖
齐墩果酸
title Synthesis of oleanolic disaccharide derivatives
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