Design,synthesis and antibacterial activity of novel 1-oxacephem analogs

A series of 1-oxacephem analogs were synthesized and their antibacterial properties against five strains of Gram-positive and Gram-negative bacteria were evaluated in vitro while ceftazidine was selected as control.Some of the tested compounds,compound 12c in particular,showed more active against th...

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Bibliographic Details
Published in:Chinese chemical letters 2012-04, Vol.23 (4), p.407-410
Main Authors: He, Yi, Wu, Jian Bo, Lei, Fan, Chen, Pei, Hai, Li, Wu, Yong
Format: Article
Language:English
Subjects:
1-Oxacephem
Antibacterial activity
Ceftazidine
Synthesis
合成
头孢他啶
小说
性能评估
抗菌活性
类似物
设计
革兰氏阴性菌
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Summary:A series of 1-oxacephem analogs were synthesized and their antibacterial properties against five strains of Gram-positive and Gram-negative bacteria were evaluated in vitro while ceftazidine was selected as control.Some of the tested compounds,compound 12c in particular,showed more active against three selected strains than the standard.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2012.01.014