Asymmetric transfer hydrogenation of ketones catalyzed by nickel complex with new PNO-type ligands

The new polydentate mixed-N,P,O chiral ligands have been synthesized by the condensation of bis（o-formylphenyl）- phenylphosphane and R-phenylglycinol in CHCl_3,and fully characterized by IR,NMR and EIMS spectra.These ligands were employed with a simple Ni complex Ni（PPh_s）_2Cl_2 in situ as catalytic...

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Bibliographic Details
Published in:Chinese chemical letters 2012-05, Vol.23 (5), p.533-536
Main Authors: Dong, Zhen Rong, Li, Yan Yun, Yu, Shen Luan, Sun, Guo Song, Gao, Jing Xing
Format: Article
Language:English
Subjects:
Asymmetric transfer hydrogenation
Ketones
Nickel complex
NPO-type ligand
不对称转移氢化
催化
光谱特征
手性配体
红外光谱
酮
镍配合物
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Summary:The new polydentate mixed-N,P,O chiral ligands have been synthesized by the condensation of bis（o-formylphenyl）- phenylphosphane and R-phenylglycinol in CHCl_3,and fully characterized by IR,NMR and EIMS spectra.These ligands were employed with a simple Ni complex Ni（PPh_s）_2Cl_2 in situ as catalytic systems for asymmetric transfer hydrogenation of ketones,and the corresponding optical alcohols were obtained with up to 84%ee under mild conditions.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2012.02.005