Colorimetric and fluorescent detection of biological thiols in aqueous solution

Biological thiols could be detected in 100% aqueous solution with high selectivity and sensitivity in physiological pH conditions. A new colorimetric and fluorescent probe, 2-(2,4-dinitrostyryl)-1,3,3-trimethyl-3H-indolium iodide (DTI), for selective and sensitive detection of biological thiols is r...

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Bibliographic Details
Published in:Chinese chemical letters 2013-02, Vol.24 (2), p.96-98
Main Authors: Li, Yin-Hui, Yang, Jin-Feng, Liu, Chang-Hui, Li, Ji-Shan, Yang, Rong-Hua
Format: Article
Language:English
Subjects:
Biological thiols
Colorimetry
Fluorescence
Michael addition
检测
比色法
水溶液
生物
硫醇
荧光法
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Summary:Biological thiols could be detected in 100% aqueous solution with high selectivity and sensitivity in physiological pH conditions. A new colorimetric and fluorescent probe, 2-(2,4-dinitrostyryl)-1,3,3-trimethyl-3H-indolium iodide (DTI), for selective and sensitive detection of biological thiols is reported. In aqueous solution at physiological pH 7.4, biological thiols react with DTI via Michael addition to give the brownish red adduct concomitant with fluorescence emission decrease.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.01.037