Selective amination of the mucohalic acid derivatives

An efficient synthesis of 4,5-diamino-3-halofuran-2（5H）-ones has been developed based on a sequential acylation and bisamination of mucohalic acids. The /5- and y-amination products have also been prepared with high regioselectivity. This reaction shows some advantages in terms of its simple operati...

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Bibliographic Details
Published in:Chinese chemical letters 2013-03, Vol.24 (3), p.202-204
Main Authors: Li, Tian-Cai, Chen, Cou-Xi, Li, Xue-Qiang, Gao, Xiao-Hui
Format: Article
Language:English
Subjects:
2(5H)-Furanones
4,5-Diamino-3-halofuran-2(5H)-ones
Amine
NMR
Selective amination
二氨基
产品
人力资源管理系统
区域选择性
羧酸衍生物
胺化
起始原料
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Summary:An efficient synthesis of 4,5-diamino-3-halofuran-2（5H）-ones has been developed based on a sequential acylation and bisamination of mucohalic acids. The /5- and y-amination products have also been prepared with high regioselectivity. This reaction shows some advantages in terms of its simple operation and readily available but highly functionalized starting material. All products gave satisfactory IR. 1H NMR. 13C NMR and HRMS.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.01.035