Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d...

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Bibliographic Details
Published in:Chinese chemical letters 2013-07, Vol.24 (7), p.619-621
Main Authors: Meng, Ying, Wang, Guan, Li, Yue, Hou, Kuan, Yuan, Yue, Zhang, Li-Juan, Song, Hong-Rui, Shi, Wei
Format: Article
Language:English
Subjects:
Antitumor
HeLa细胞
Pyrrolopyrazinone
Synthesis
化合物
合成
吡嗪酮
抗肿瘤剂
抗肿瘤活性
生物评价
细胞毒活性
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Summary:A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.04.020