Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold

A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~1H NMR,~（13）C NMR,~（19）F NMR and HRMS.The preliminary bioassays indicated that half...

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Bibliographic Details
Published in:Chinese chemical letters 2013-08, Vol.24 (8), p.673-676
Main Authors: Chen, Yin-Bo, Li, Ji-Ling, Shao, Xu-Sheng, Xu, Xiao-Yong, Li, Zhong
Format: Article
Language:English
Subjects:
Anthranilic diamides
Benzyl sulfide
Insecticidal activity
Synthesis
二酰胺
人力资源管理系统
合成化合物
杀虫活性
标题化合物
脚手架
苯硫醚
设计
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Summary:A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~1H NMR,~（13）C NMR,~（19）F NMR and HRMS.The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm（Mythimna sepatara） at the concentration of 500 mg/L,Exhilaratingly,the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L.The difference in activities between the target compounds was influenced by the substituents,which provided some hints for further investigation on structure modifications.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.04.047