An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation

An efficient synthesis of substituted 1,4-diazepines is developed.The accessible intermediates have been obtained via Pd-catalyzed amination.The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation.The mild and genera...

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Bibliographic Details
Published in:Chinese chemical letters 2013-08, Vol.24 (8), p.743-746
Main Authors: Wang, Xiao-Jian, Tian, Yu-Lin, Zhang, Qing-Yang, Qi, Jian-Guo, Yin, Da-Li
Format: Article
Language:English
Subjects:
1,4-Diazepines
Hydrogenation
Intramolecular condensation
Pd-catalyzed amination
二氮杂
催化氨化
催化胺化
分子内缩合
加氢
综合开发
钯
高效合成
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Summary:An efficient synthesis of substituted 1,4-diazepines is developed.The accessible intermediates have been obtained via Pd-catalyzed amination.The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation.The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2013.04.028