Porous graphene decorated silica as a new stationary phase for separation of sulfanilamide compounds in hydrophilic interaction chromatography

Porous graphene (PG) was prepared by combustion method and then coated onto aminopropyl-silica in deep eutectic solven nb ts (DESs). PG-modified silica was evaluated in hydrophilic interaction chromatography for the separation and determination of sulfonamides in human serum samples. [Display omitte...

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Bibliographic Details
Published in:Chinese chemical letters 2019-04, Vol.30 (4), p.863-866
Main Authors: Song, Lijun, Zhang, Haijuan, Cai, Tianpei, Chen, Jia, Li, Zhan, Guan, Ming, Qiu, Hongdeng
Format: Article
Language:English
Subjects:
Human serum samples
Hydrophilic interaction chromatography
Porous graphene
Stationary phase
Sulfonamides
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Summary:Porous graphene (PG) was prepared by combustion method and then coated onto aminopropyl-silica in deep eutectic solven nb ts (DESs). PG-modified silica was evaluated in hydrophilic interaction chromatography for the separation and determination of sulfonamides in human serum samples. [Display omitted] Porous graphene (PG) has potential applications in numerous fields because of the existence of nanopores in the plane. In this study, porous graphene decorated silica microspheres (Sil-PG) were successfully fabricated by assembling PG onto the silica particles surface in deep eutectic solvents (DESs). Experimental results demonstrate that this new stationary phase can facilitate the separation of six sulfonamides compounds in hydrophilic chromatographic conditions. The successful synthesis of the Sil-PG stationary phase provides a basis for the application of porous graphene-modified materials as the stationary phase for liquid chromatography, and offers the possibility to broaden the application of PG in the field of chromatography.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2018.10.040