Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction

Using continuous-flow synthesis of nitriles by Schmidt reaction, a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up...

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Published in:Chinese chemical letters 2019-05, Vol.30 (5), p.973-976
Main Authors: Zhan, Wei, Tong, Meng, Ji, Ling, Zhang, Han, Ge, Zemei, Wang, Xin, Li, Runtao
Format: Article
Language:English
Subjects:
Aldehydes
Continuous-flow reaction
Nitriles
Safety
Schmidt reaction
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description Using continuous-flow synthesis of nitriles by Schmidt reaction, a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up. [Display omitted] A continuous-flow synthesis of nitriles by Schmidt reaction has been developed. Using this procedure, a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up.
doi_str_mv 10.1016/j.cclet.2019.01.006
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subjects Aldehydes
Continuous-flow reaction
Nitriles
Safety
Schmidt reaction
title Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction
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