Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair

A kind of nanomaterial of hollow PtPd nanocubes was produced, and they showed good radiation protection capabilities both in vitro and in vivo by scavenging free radicals. [Display omitted] Radiotherapy is one of the most important clinical cancer treatments, which works mainly by delivering a presc...

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Bibliographic Details
Published in:Chinese chemical letters 2020-01, Vol.31 (1), p.269-274
Main Authors: Long, Wei, Wang, Jingya, Xu, Fujuan, Wu, Hongying, Mu, Xiaoyu, Wang, Junying, Sun, Yuanming, Zhang, Xiao-Dong
Format: Article
Language:English
Subjects:
Bimetal
High-index facets
Nanocrystals
Radiation injury
Radiation protection
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Summary:A kind of nanomaterial of hollow PtPd nanocubes was produced, and they showed good radiation protection capabilities both in vitro and in vivo by scavenging free radicals. [Display omitted] Radiotherapy is one of the most important clinical cancer treatments, which works mainly by delivering a prescribed radiation dose to the tumor tissues. However, high doses of radiation may also lead many irreversible damages to the surrounding normal tissues. Thereby, how to effectively reduce these side-effects has been a significant factor in influencing cancer therapeutic effect. In this work, we synthesized the hollow PtPd nanocubes with high-index facets, and investigated the radiation protection capability in vitro and in vivo. Our results showed the PtPd nanocrystals can decrease the ROS level and improve the survival rate of radiated cells. Meanwhile, survival rate of radiated mice can significantly increase from 0 to 30% after PtPd treatment. Consequently, the enzyme and ROS level in radiated mice can be recovered.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2019.03.044