Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes

Red carbon dots (RCD) are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA. This nanoprobe features excellent selectivity, good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section. In addition, RCD have bee...

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Published in:Chinese chemical letters 2020-03, Vol.31 (3), p.759-763
Main Authors: Wang, Hong, Wei, Jing, Zhang, Chonghua, Zhang, Yuan, Zhang, Yubin, Li, Lin, Yu, Changmin, Zhang, Peisheng, Chen, Jian
Format: Article
Language:English
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Carbon dots (CDs)
Formaldehyde (FA)
Intracellular imaging
Two-photon excitation
Zebrafishes
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description Red carbon dots (RCD) are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA. This nanoprobe features excellent selectivity, good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section. In addition, RCD have been applied for monitoring FA in live cells and zebrafishes with OPM and TPM. [Display omitted] Direct, in situ selective detection of intracellular formaldehyde (FA) is of great significance for understanding its function in FA-related diseases. Herein, red carbon dots (RCD) are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA. Upon addition of FA, the -NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water. In addition, the nanoprobes exhibit outstanding photostability, rapid response (
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This nanoprobe features excellent selectivity, good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section. In addition, RCD have been applied for monitoring FA in live cells and zebrafishes with OPM and TPM. [Display omitted] Direct, in situ selective detection of intracellular formaldehyde (FA) is of great significance for understanding its function in FA-related diseases. Herein, red carbon dots (RCD) are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA. Upon addition of FA, the -NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water. In addition, the nanoprobes exhibit outstanding photostability, rapid response (&lt;1 min), high sensitivity (∼9.9 μmol/L) and excellent selectivity toward FA over other aldehyde group compounds. Notably, owing to the good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section, the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation. Moreover, RCD could stain the tissue of zebrafishes at depths interval of up to 240 μm under two-photon excitation. This research implied that RCD are promising tools for directly and in situ imaging FA in vivo, thus providing critical insights into FA-related pathophysiological processes.</description><identifier>ISSN: 1001-8417</identifier><identifier>EISSN: 1878-5964</identifier><identifier>DOI: 10.1016/j.cclet.2019.09.021</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Carbon dots (CDs) ; Formaldehyde (FA) ; Intracellular imaging ; Two-photon excitation ; Zebrafishes</subject><ispartof>Chinese chemical letters, 2020-03, Vol.31 (3), p.759-763</ispartof><rights>2020 The Author</rights><rights>Copyright © Wanfang Data Co. Ltd. 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This nanoprobe features excellent selectivity, good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section. In addition, RCD have been applied for monitoring FA in live cells and zebrafishes with OPM and TPM. [Display omitted] Direct, in situ selective detection of intracellular formaldehyde (FA) is of great significance for understanding its function in FA-related diseases. Herein, red carbon dots (RCD) are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA. Upon addition of FA, the -NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water. In addition, the nanoprobes exhibit outstanding photostability, rapid response (&lt;1 min), high sensitivity (∼9.9 μmol/L) and excellent selectivity toward FA over other aldehyde group compounds. Notably, owing to the good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section, the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation. Moreover, RCD could stain the tissue of zebrafishes at depths interval of up to 240 μm under two-photon excitation. 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Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 211800, China%Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparationand Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, Hunan Province College KeyLaboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China</general><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><orcidid>https://orcid.org/0000-0002-4890-8742</orcidid><orcidid>https://orcid.org/0000-0003-0426-6546</orcidid><orcidid>https://orcid.org/0000-0002-3329-6384</orcidid></search><sort><creationdate>20200301</creationdate><title>Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes</title><author>Wang, Hong ; 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This nanoprobe features excellent selectivity, good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section. In addition, RCD have been applied for monitoring FA in live cells and zebrafishes with OPM and TPM. [Display omitted] Direct, in situ selective detection of intracellular formaldehyde (FA) is of great significance for understanding its function in FA-related diseases. Herein, red carbon dots (RCD) are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA. Upon addition of FA, the -NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water. In addition, the nanoprobes exhibit outstanding photostability, rapid response (&lt;1 min), high sensitivity (∼9.9 μmol/L) and excellent selectivity toward FA over other aldehyde group compounds. Notably, owing to the good cell-membrane permeability and biocompatibility, as well as the large two-photon absorption cross-section, the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation. Moreover, RCD could stain the tissue of zebrafishes at depths interval of up to 240 μm under two-photon excitation. 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subjects Carbon dots (CDs)
Formaldehyde (FA)
Intracellular imaging
Two-photon excitation
Zebrafishes
title Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes
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