Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2

Nanoscale ZIF-8 had a high inhibitory effect on pyruvate kinase of M2. [Display omitted] Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy. The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase (especially M2-type iso...

Full description

Saved in:
Bibliographic Details
Published in:Chinese chemical letters 2021-10, Vol.32 (10), p.3087-3089
Main Authors: Ren, Xiangling, Huang, Xinyuan, Wu, Qiong, Tan, Longfei, Fu, Changhui, Chen, Yi, Meng, Xianwei
Format: Article
Language:English
Subjects:
Glycolysis
Inhibition
Lactate dehydrogenase
Metal organic frameworks
Pyruvate kinase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanoscale ZIF-8 had a high inhibitory effect on pyruvate kinase of M2. [Display omitted] Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy. The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase (especially M2-type isozyme, PKM2), the rate limiting enzyme of glycolysis. This is helpful to the treatment of tumor. Herein, metal organic frameworks (MOFs) were found to inhibit the activity of PKM2. Nanoscale ZIF-8 was synthesized by standing and ultrasonic method, respectively. The ZIF-8 has the performance of inhibiting PKM2. Further research showed that the inhibition ability was attributed to zinc ion in ZIF-8. Interestingly, the IC50 of ZIF-8 on PKM2 was one percent of that of zinc ion. This novel enzyme inhibitor is expected to be used in cancer therapy.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2021.03.081