Effect of quercetin on chronic enhancement of spatial learning and memory of mice

In this study we evaluated the effect of quercetin on D-galactose-induced aged mice using the Morris water maze (MWM) test. Based on the free radical theory of aging, experiments were performed to study the possible biochemical mechanisms of glutathione (GSH) level and hydroxyl radical (OH-) in the...

Full description

Saved in:
Bibliographic Details
Published in:Science China. Life sciences 2006-12, Vol.49 (6), p.583-590
Main Authors: Liu, Jiancai, Yu, Huqing, Ning, Xinbao
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - physiology
Animals
Antioxidants - pharmacology
Antioxidants - physiology
Learning - drug effects
Learning - physiology
Memory - drug effects
Memory - physiology
Mice
Quercetin - pharmacology
Quercetin - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study we evaluated the effect of quercetin on D-galactose-induced aged mice using the Morris water maze (MWM) test. Based on the free radical theory of aging, experiments were performed to study the possible biochemical mechanisms of glutathione (GSH) level and hydroxyl radical (OH-) in the hippocampus and cerebral cortex and the brain tissue enzyme activity of the mice. The results indicated that quercetin can enhance the exploratory behavior, spatial learning and memory of the mice. The effects relate with enhancing the brain functions and inhibiting oxidative stress by quercetin, and relate with increasing the GSH level and decreasing the OH- content. These findings suggest that quercetin can work as a possible natural anti-aging pharmaceutical product.
ISSN:1006-9305
1674-7305
1862-2798
1869-1889
DOI:10.1007/s11427-006-2037-7