A Novel Angiotensin I Converting Enzyme Inhibitory Peptide from the Milk Casein：Virtual Screening and Docking Studies

Angiotensin I converting enzyme （ACE） plays an important physiological role in the regulation of hypertension. In this study, we applied virtual screening to discover a novel angiotensin I converting enzyme inhibitory peptides from milk casein. One potential hit was identified based on docking score...

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Bibliographic Details
Published in:Agricultural sciences in China 2011-03, Vol.10 (3), p.463-467
Main Authors: WANG, Zhan-li, ZHANG, Sai-sai, WANG, Wei, FENG, Feng-qin, SHAN, Wei-guang
Format: Article
Language:English
Subjects:
casein
docking
hypertension
IC50
in vitro studies
inhibitory peptide
milk
novel angiotensin I converting enzyme
peptides
peptidyl-dipeptidase A
screening
virtual screening
体外活性
异亮氨酸
生理调节
虚拟筛选
血管紧张素转换酶抑制肽
酪蛋白
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Summary:Angiotensin I converting enzyme （ACE） plays an important physiological role in the regulation of hypertension. In this study, we applied virtual screening to discover a novel angiotensin I converting enzyme inhibitory peptides from milk casein. One potential hit was identified based on docking scores, subsequently confirmed by activity studies in vitro （IC50=20.85 μmol L-1）. The proposed peptide in this study contains a unique sequence, Lys-Val-Leu-Ile-Leu-Ala. Moreover, we performed the docking studies to understand the binding mode between the enzyme and peptide hit.
ISSN:1671-2927
DOI:10.1016/S1671-2927(11)60026-6