Sciatic nerve repair using adhesive bonding and a modiifed conduit

• Published in: 中国神经再生研究（英文版） 2014 (6), p.594-601
• Main Authors: Xiangdang Liang, Hongfei Cai, Yongyu Hao, Geng Sun, Yaoyao Song, Wen Chen
• Format: Article
• Language: English
• ISSN: 1673-5374
• DOI: 10.4103/1673-5374.130099

When repairing nerves with adhesives, most researchers place glue directly on the nerve stumps, but this method does not ifx the nerve ends well and allows glue to easily invade the nerve ends. In this study, we established a rat model of completely transected sciatic nerve injury and re-paired it using a modiifed 1 cm-length conduit with inner diameter of 1.5 mm. Each end of the cylindrical conduit contains a short linear channel, while the enclosed central tube protects the nerve ends well. Nerves were repaired with 2-octyl-cyanoacrylate and suture, which complement the function of the modiifed conduit. The results demonstrated that for the same conduit, the av-erage operation time using the adhesive method was much shorter than with the suture method. No signiifcant differences were found between the two groups in sciatic function index, motor evoked potential latency, motor evoked potential amplitude, muscular recovery rate, number of medullated nerve fibers, axon diameter, or medullary sheath thickness. Thus, the adhesive method for repairing nerves using a modiifed conduit is feasible and effective, and reduces the operation time while providing an equivalent repair effect.