Apelin-13 as a novel target for intervention in secondar y injur y after traumatic brain injur y

The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy. However, secondary apelin-13 effects on traumatic brain injury-induced neural cell...

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Bibliographic Details
Published in:中国神经再生研究（英文版） 2016, Vol.11 (7), p.1128-1133
Main Authors: Hai-jun Bao, Hai-yang Qiu, Jin-xia Kuai, Cheng-jie Song, Shao-xian Wang, Chao-qun Wang, Hua-bin Peng, Wen-can Han, Yong-ping Wu
Format: Article
Language:English
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Summary:The adipocytokine, apelin-13, is an abundantly expressed peptide in the nervous system. Apelin-13 protects the brain against ischemia/reperfusion injury and attenuates traumatic brain injury by suppressing autophagy. However, secondary apelin-13 effects on traumatic brain injury-induced neural cell death and blood-brain barrier integrity are still not clear. Here, we found that apelin-13 signiifcantly de-creases cerebral water content, mitigates blood-brain barrier destruction, reduces aquaporin-4 expression, diminishes caspase-3 and Bax expression in the cerebral cortex and hippocampus, and reduces apoptosis. These results show that apelin-13 attenuates secondary injury after traumatic brain injury and exerts a neuroprotective effect.
ISSN:1673-5374
DOI:10.4103/1673-5374.187049