Computed tomography perfusion and computed tomography angiography for prediction of clinical outcomes in ischemic stroke patients atfer thrombolysis

• Published in: 中国神经再生研究（英文版） 2017, Vol.12 (1), p.103-108
• Main Authors: Jia-wei Pan, Xiang-rong Yu, Shu-yi Zhou, Jian-hong Wang, Jun Zhang, Dao-ying Geng, Tian-yu Zhang, Xin Cheng, Yi-feng Ling, Qiang Dong
• Format: Article
• Language: English
• ISSN: 1673-5374
• DOI: 10.4103/1673-5374.198994

Cerebral blood perfusion and cerebrovascular lesions are important factors that can affect the therapeutic effcacy of thrombolysis. At pres-ent, the majority of studies focus on assessing the accuracy of lesion location using imaging methods before treatment, with less attention to predictions of outcomes atfer thrombolysis. hTus, in the present study, we assessed the effcacy of combined computed tomography (CT) perfusion and CT angiography in predicting clinical outcomes atfer thrombolysis in ischemic stroke patients. hTe study included 52 patients who received both CT perfusion and CT angiography. Patients were grouped based on the following criteria to compare clinical outcomes:(1) thrombolytic and non-thrombolytic patients, (2) thrombolytic patients with CT angiography showing the presence or ab-sence of a vascular stenosis, (3) thrombolytic patients with CT perfusion showing the presence or absence of hemodynamic mismatch, and (4) different CT angiography and CT perfusion results. Short-term outcome was assessed by the 24-hour National Institution of Health Stroke Scale score change. Long-term outcome was assessed by the 3-month modiifed Rankin Scale score. Of 52 ischemic stroke patients, 29 were treated with thrombolysis and exhibited improved short-term outcomes compared with those without thrombolysis treatment (23 patients). Patients with both vascular stenosis and blood lfow mismatch (13 patients) exhibited the best short-term outcome, while there was no correlation of long-term outcome with CT angiography or CT perfusion ifndings. hTese data suggest that combined CT perfusion and CT angiography are useful for predicting short-term outcome, but not long-term outcome, atfer thrombolysis.