Effects of Shehuang Paste on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites

To explore the influence of Shehuang Paste (SHP) to the hemodynamics, endotoxin, nitric oxide (NO), and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups, 32 cases in the treatment group and 27 cas...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2006-12, Vol.12 (4), p.255-261
Main Authors: Tong, Guang-dong, Zhou, Da-qiao, He, Jin-song, Li, Song-lin, Peng, Li-sheng
Format: Article
Language:English
Subjects:
Adult
Endothelin-1 - blood
Endotoxins - blood
Female
Follow-Up Studies
Humans
Liver - drug effects
Liver - physiopathology
Liver Cirrhosis - blood
Liver Cirrhosis - drug therapy
Liver Cirrhosis - physiopathology
Male
Medicine, Chinese Traditional
Middle Aged
Nitric Oxide - blood
Portal Vein - drug effects
Portal Vein - physiopathology
Potassium - metabolism
Regional Blood Flow - drug effects
Sodium - metabolism
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Summary:To explore the influence of Shehuang Paste (SHP) to the hemodynamics, endotoxin, nitric oxide (NO), and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups, 32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups, including liver protecting medicines, diuretics and supportive drugs, but SHP navel sticking was applied for the treatment group additionally once a day. A course of one month of treatment was applied and the general efficacy on ascites was observed by the end of the therapeutic course. Before and after the treatment, examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly, radioimmunoassay to measure plasma ET-1 content; and color Doppler ultrasonography to measure the blood flow of portal vein and splenic vein. The relationship between the blood flow of portal vein and splenic vein and endotoxin, NO and ET-1 in the treatment group was analyzed as well. The total effective rate on ascites was 84.4% in the treatment group, and 48. 1% in the control group, with significant difference shown between them (P
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-006-0255-4