Effect of modified wuzi yanzong granule on patients with mild cognitive impairment from oxidative damage aspect

To observe the effects of modified Wuzi Yanzong Granule (WYG) on memory function and the activity of serum superoxide dismutase (SOD), malondialdehyde (MDA) levels, leukocyte mitochondrial DNA (mtDNA) deletion rate and beta-amyloid protein(1-28) (A beta(1-28)) in patients with mild cognitive impairm...

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Published in:Chinese journal of integrative medicine 2007-12, Vol.13 (4), p.258-263
Main Authors: Wang, Xue-mei, Fu, Hong, Liu, Geng-xin, Zhu, Wei, Li, Li, Yang, Jin-xia
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Amyloid beta-Peptides - blood
Cognition Disorders - blood
Cognition Disorders - drug therapy
Cognition Disorders - etiology
Cognition Disorders - pathology
Disease Progression
DNA, Mitochondrial - genetics
Double-Blind Method
Drug Compounding
Drugs, Chinese Herbal - administration & dosage
Female
Humans
Male
Malondialdehyde - blood
Memory - drug effects
Middle Aged
Oxidative Stress - physiology
Peptide Fragments - blood
Phytotherapy
Placebos
Superoxide Dismutase - blood
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creator Wang, Xue-mei
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description To observe the effects of modified Wuzi Yanzong Granule (WYG) on memory function and the activity of serum superoxide dismutase (SOD), malondialdehyde (MDA) levels, leukocyte mitochondrial DNA (mtDNA) deletion rate and beta-amyloid protein(1-28) (A beta(1-28)) in patients with mild cognitive impairment (MCI). Thirty-six patients with MCI were selected based on the internationally recognized Petersen's criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A beta(1-28) content were observed before and after treatment. Compared with the normal control group, the memory quotient and SOD activity in patients with MCI decreased significantly (P < 0.01), while MDA, A beta(1-28) levels and the leukocyte mtDNA deletion rate increased significantly (P < 0.01). After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A beta(1-28) level decreased in the treated group compared with those before treatment (P
doi_str_mv 10.1007/s11655-007-0258-7
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Thirty-six patients with MCI were selected based on the internationally recognized Petersen's criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A beta(1-28) content were observed before and after treatment. Compared with the normal control group, the memory quotient and SOD activity in patients with MCI decreased significantly (P &lt; 0.01), while MDA, A beta(1-28) levels and the leukocyte mtDNA deletion rate increased significantly (P &lt; 0.01). After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A beta(1-28) level decreased in the treated group compared with those before treatment (P&lt;0.01, P&lt;0.05). Meanwhile, leukocyte mtDNA deletion rate and A beta(1-28) content in the treated group were all lower than those in the control group (P&lt;0.05). WYG could improve memory function in patients with MCI and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase, the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. 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Thirty-six patients with MCI were selected based on the internationally recognized Petersen's criteria, and equally and randomly assigned to two groups. The treated group was treated with WYG and the control group was treated with placebo for 3 months. In addition, 20 healthy subjects were included in the study as the normal control group. Changes of memory function, SOD activity, MDA content, leukocyte mtDNA deletion rate and A beta(1-28) content were observed before and after treatment. Compared with the normal control group, the memory quotient and SOD activity in patients with MCI decreased significantly (P &lt; 0.01), while MDA, A beta(1-28) levels and the leukocyte mtDNA deletion rate increased significantly (P &lt; 0.01). After treatment, levels of memory quotient and serum SOD activity increased while the serum MDA level, leukocyte mtDNA deletion rate and A beta(1-28) level decreased in the treated group compared with those before treatment (P&lt;0.01, P&lt;0.05). Meanwhile, leukocyte mtDNA deletion rate and A beta(1-28) content in the treated group were all lower than those in the control group (P&lt;0.05). WYG could improve memory function in patients with MCI and the therapeutic mechanism is possibly related to the increased activity of anti-oxidase, the improved free radical metabolism and the alleviation of leukocyte mtDNA oxidation damage. WYG shows clinical significance in delaying the progression of MCI.</abstract><cop>China</cop><pub>Department of Integrated Chinese and Western Medicine of Peking University First Hospital,Beijing,100034</pub><pmid>18180889</pmid><doi>10.1007/s11655-007-0258-7</doi><tpages>6</tpages></addata></record>
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ispartof Chinese journal of integrative medicine, 2007-12, Vol.13 (4), p.258-263
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1993-0402
language eng
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source Springer Nature
subjects Aged
Aged, 80 and over
Amyloid beta-Peptides - blood
Cognition Disorders - blood
Cognition Disorders - drug therapy
Cognition Disorders - etiology
Cognition Disorders - pathology
Disease Progression
DNA, Mitochondrial - genetics
Double-Blind Method
Drug Compounding
Drugs, Chinese Herbal - administration & dosage
Female
Humans
Male
Malondialdehyde - blood
Memory - drug effects
Middle Aged
Oxidative Stress - physiology
Peptide Fragments - blood
Phytotherapy
Placebos
Superoxide Dismutase - blood
title Effect of modified wuzi yanzong granule on patients with mild cognitive impairment from oxidative damage aspect
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