Effect of volatile oil of amomum on expressions of platelet activating factor and mastocarcinoma-related peptide in the gastric membrane of chronic gastritis patients with helicobacter-pylori infection

Objective To observe the effect of volatile oil of amomum (VOA) on the expressions of mastocarcinoma-related peptide (PS 2 ) and platelet activating factor (PAF) in helicobacter pyloriassociated gastritis (HPG) and to analyze its potential mechanism. Methods Eighty patients with HPG were randomly as...

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Bibliographic Details
Published in:Chinese journal of integrative medicine 2008-03, Vol.14 (1), p.23-27
Main Authors: Huang, Guo-dong, Huang, Yuan-hua, Xiao, Mei-zhen, Huang, Dao-fu, Liu, Juan, Li, Jia-bang
Format: Article
Language:English
Subjects:
Adult
Aged
Amomum
Blotting, Western
Chronic Disease
Female
Gastric Mucosa - chemistry
Gastritis - drug therapy
Gastritis - metabolism
Helicobacter Infections - drug therapy
Helicobacter Infections - metabolism
Helicobacter pylori
Humans
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Middle Aged
Oils, Volatile - adverse effects
Oils, Volatile - therapeutic use
Original Article
Peptides - analysis
Phospholipids - analysis
Platelet Activating Factor - analysis
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Summary:Objective To observe the effect of volatile oil of amomum (VOA) on the expressions of mastocarcinoma-related peptide (PS 2 ) and platelet activating factor (PAF) in helicobacter pyloriassociated gastritis (HPG) and to analyze its potential mechanism. Methods Eighty patients with HPG were randomly assigned to two groups, 42 patients in the treated group treated with 0.5 mL VOA, thrice per day; and the 38 patients in the control group receiving Western tertiary medicinal treatment. Gastroscopic picture and helicobacter pylori (HP) infection (by quick urease and Warthin-Starry stain) of the gastro-membrane, expressions of PS 2 and PAF (by immunohistochemical assay and Western blotting) as well as the contents of aminohexose and phospholipid (by Neuhaus method) in the gastric membrane of all patients were detected before treatment and 4 weeks after treatment. The clinical effi cacy in the two groups was compared. Results The total effective rate in the treated group was 88.1%, which was significantly higher than that in the control group (78.9%, P
ISSN:1672-0415
1993-0402
DOI:10.1007/s11655-008-0023-6