Effect of Jieze No.1 (洁泽 号) on cervicitis caused by ureaplasma urealyticum and on ureaplasma urealyticum in vitro

• Published in: Chinese journal of integrative medicine 2008-06, Vol.14 (2), p.88-93
• Main Authors: Wei, Hong, Chen, Zhuo, Xu, Ping, Ma, Yong-gui, Xu, Li-jun
• Format: Article
• Language: English
• Subjects: Adult; Drug Resistance, Bacterial - drug effects; Drug Therapy, Combination; Drugs, Chinese Herbal - adverse effects; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Female; Humans; Medicine; Medicine & Public Health; Microbial Sensitivity Tests; Middle Aged; Original Article; Ureaplasma urealyticum - drug effects; Uterine Cervicitis - drug therapy; Uterine Cervicitis - microbiology
• ISSN: 1672-0415; 1993-0402
• DOI: 10.1007/s11655-008-0088-2

Objective To observe the clinical therapeutic effect of Jieze No. 1 (洁泽 I 号) on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum (Uu) in vitro . Methods A total of 393 patients suffering from cervicitis induced by ureaplasma urealyticum without other complications were randomly assigned to 3 groups, the combined treatment group: 140 patients treated with Chinese herbs Jieze No.1 by vaginal lavage, 30 min each time, once a day for 10 consecutive days and oral administration of Azithromycin, 1.0 g once every 72 h for three times; Jieze group: 115 patients were treated with Jieze No.1 alone by vaginal lavage, 30 min each time, once a day for 10 consecutive days; and the Azithromycin group: 138 patients were treated with oral administration of Azithromycin, 1.0 g once in 72 h for three times. All the patients were treated for 1 therapeutic course and condom were used for contraception during the treatment course. The Uu patients were examined again after 21 days of treatment. The therapeutic effect on cervicitis was observed. The experimental study of Jieze No. 1 on the Uu strain separated from the secretion of the urogenital tract was also observed. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the Uu were investigated. Results The total effective rate of the combined group was 85.3%, showing a significant difference compared with the Jieze group (67.8%) and the Azithromycin group (60.3%, both P 0.05). The clearing rate of Uu in the combined group was 78.4%, that of the Jieze group was 60.9% and the Azithromycin group was 47.9%. The combined group also showed a significant difference in comparison with the other two groups (all P