T-bet/GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients

• Published in: Chinese medical journal 2006-08, Vol.119 (16), p.1396-1399
• Main Authors: Dong, Liang, Chen, Ming, Zhang, Qi, Li, Li-zheng, Xu, Xiao-qun, Xiao, Wei
• Format: Article
• Language: English
• Subjects: Adjuvants, Immunologic - pharmacology; Asthma - blood; Cells, Cultured; Cytokines - metabolism; Enzyme-Linked Immunosorbent Assay - methods; Female; GATA3 Transcription Factor - genetics; GATA3 Transcription Factor - metabolism; Humans; Interferon-gamma - metabolism; Interleukin-13 - metabolism; Interleukin-4 - metabolism; Interleukin-5 - metabolism; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - metabolism; Male; Oligodeoxyribonucleotides - pharmacology; Pulmonary Disease, Chronic Obstructive - blood; Reverse Transcriptase Polymerase Chain Reaction - methods; RNA, Messenger - genetics; RNA, Messenger - metabolism; Statistics as Topic; T-Box Domain Proteins; T-Lymphocytes, Helper-Inducer - cytology; T-Lymphocytes, Helper-Inducer - drug effects; T-Lymphocytes, Helper-Inducer - metabolism; Th1 Cells - cytology; Th1 Cells - drug effects; Th1 Cells - metabolism; Th2 Cells - cytology; Th2 Cells - drug effects; Th2 Cells - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; 发病机制; 细胞因子
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/00029330-200608020-00013

Naive helper T （Th） cells are divided into two subsets, Th1 and Th2. Th1 cells produce predominantly interferon- 7 （IFN- γ）, and Th2 cells produce interleukin-4 （IL-4）, IL-5 and IL-13, but not IFN-γ. In asthma, an imbalance in the Th1/Th2 cytokine ratio characterized with a shift towards a predominantly Th2 cytokine profile in asthma occurs.2 The differentiation of naive helper T cells towards Th1 or Th2 cells is regulated by the ranscription factors T-box expressed in T-cells （T-bet） and GATA-binding protein-3 （GATA-3）.