Effects of 5-hydroxytryptamine ascending pathways of dorsal raphe nuclei and habenular nucleus on the respiration and blood pressure of rats

Obstructive sleep apnea syndrome （OSAS） was a disease of breath obstacle happened in the process of sleep. The central mechanism of OSAS has not yet been fully elucidated. Most of studies focused on raphe nuclei and 5-hydroxytryptamine （5-HT）, and showed that brain serotonergic activity might be dec...

Full description

Saved in:
Bibliographic Details
Published in:Chinese medical journal 2007-12, Vol.120 (24), p.2308-2310
Main Authors: Yu, Lei, Huang, Min, Xu, Hai-yan, Zhao, Hua
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Electric Stimulation
Female
Habenula - physiology
Lidocaine - pharmacology
Male
Raphe Nuclei - physiology
Rats
Rats, Wistar
Respiration - drug effects
Serotonin - physiology
利多卡因
复合胺
细胞核
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obstructive sleep apnea syndrome （OSAS） was a disease of breath obstacle happened in the process of sleep. The central mechanism of OSAS has not yet been fully elucidated. Most of studies focused on raphe nuclei and 5-hydroxytryptamine （5-HT）, and showed that brain serotonergic activity might be decreased in OSAS. It is well known that the dorsal and medial raphe nuclei provide almost all the serotonergic innervation to the forebrain. A previous study evaluated the stimulation of the dorsal raphe nuclei （DRN） in the rat inducing mainly pressor and sympathoexcitatory responses.
ISSN:0366-6999
2542-5641
DOI:10.1097/00029330-200712020-00029