β-catenin expression pattern in primary oral squamous cell carcinoma

• Published in: Chinese medical journal 2008-10, Vol.121 (19), p.1866-1870
• Main Authors: Cai, Zhi-gang, Shi, Xiao-jian, Gao, Yan, Wei, Ming-jie, Wang, Cun-yu, Yu, Guang-yan
• Format: Article
• Language: English
• Subjects: beta Catenin - analysis; Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - pathology; Female; Humans; Immunohistochemistry; Male; Middle Aged; Mouth Mucosa - chemistry; Mouth Neoplasms - chemistry; Mouth Neoplasms - pathology; 免疫组织化学; 口腔肿瘤; 基因表达; 鳞状细胞癌
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/00029330-200810010-00003

Background β--catenin, a 92 kDa protein that binds to the cytoplasmic tail of E-cadherin, has an essential role in intercellular adhesion and signal transduction. Aberrant expression of β-catenin has been associated with progression and metastasis of various human cancers. The aim of this study was to elucidate the expression pattern of β-catenin in primary oral squamous cell carcinoma and examine the correlation between β-catenin expression and tumor differentiation, histological grade and lymph node status as well as its clinical significances. Methods Seventy-six patients with oral squamous cell carcinoma and sixteen metastatic lymph nodes were studied. The β-catenin expression was determined by immunohistochemical staining. The correlation with clinical, histological data was analyzed statistically. Results Normal oral epithelium showed strong β-catenin expression at the cell membrane, but no cytoplasmic or nuclear expression. Different degrees of reduced expression of β-catenin at the cell membrane were found in 54 cases with squamous cell carcinoma （71%）. Cytoplasmic β-catenin expression was found in 17 tumors （22.4%）. Three cases were found with nuclear β-catenin expression. In sixteen lymph nodes with metastatic squamous cell carcinoma, negative β-catenin expression at the cell membrane was seen in 13 tumors （81.2%） and weak expression in 3 tumors （18.8%）. Statistical analysis showed that there was an inverse correlation between β-catenin expression and lymph node status and histological grade of tumors. Conclusions Reduced β-catenin expression at the cell membrane is clearly associated with lymph node metastasis. A reduced expression of β-catenin may constitute a hallmark of aggressive biological behavior of squamous cell carcinoma.