Establishment of cervical lymph node metastasis model of squamous cell carcinoma in the oral cavity in mice

Background Oral squamous cell carcinoma （OSCC） is the most prevalent malignant tumor in the head and neck region, comprising more than 90% of all oral malignancies. A feasible approach for an animal model to study OSCC lymph node metastasis was established and biological behaviors of three oral squa...

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Published in:Chinese medical journal 2008-10, Vol.121 (19), p.1891-1895
Main Authors: Sun, Rui, Zhang, Jian-gang, Guo, Chuan-bin
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Squamous Cell - pathology
Cell Line, Tumor
Humans
Lymphatic Metastasis
Mice
Mice, Inbred BALB C
Mouth Neoplasms - pathology
Neck
动物模型
口腔肿瘤
淋巴节转移
鳞状细胞癌
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cited_by cdi_FETCH-LOGICAL-c487t-52553661213004206c90ca05eee9fb6abee25723d5f55fe36ed8f19aab8b79333
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container_issue 19
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container_title Chinese medical journal
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creator Sun, Rui
Zhang, Jian-gang
Guo, Chuan-bin
description Background Oral squamous cell carcinoma （OSCC） is the most prevalent malignant tumor in the head and neck region, comprising more than 90% of all oral malignancies. A feasible approach for an animal model to study OSCC lymph node metastasis was established and biological behaviors of three oral squamous cell carcinoma cell lines were compared. Methods After implanting three kinds of cell lines （GDC185, Tca8113, Tca83） into three different anatomical sites in nude mice, namely the tongue, floor of the mouth, and axillary fossa, we observed the tumorigenicity and the metastatic capacity, which was confirmed by histopathology under a surgical microscope. Results The animal model injected with GDC185 cells into the floor of the mouth had the highest rate of neck lymph node metastasis （55.6%） and the cell lines had significantly different biological behaviors. Conclusions Nude mice injected with GDC185 cells into the floor of the mouth could be used as a feasible animal model to study neck metastasis of oral squamous cell carcinoma.
doi_str_mv 10.1097/00029330-200810010-00007
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A feasible approach for an animal model to study OSCC lymph node metastasis was established and biological behaviors of three oral squamous cell carcinoma cell lines were compared. Methods After implanting three kinds of cell lines （GDC185, Tca8113, Tca83） into three different anatomical sites in nude mice, namely the tongue, floor of the mouth, and axillary fossa, we observed the tumorigenicity and the metastatic capacity, which was confirmed by histopathology under a surgical microscope. Results The animal model injected with GDC185 cells into the floor of the mouth had the highest rate of neck lymph node metastasis （55.6%） and the cell lines had significantly different biological behaviors. Conclusions Nude mice injected with GDC185 cells into the floor of the mouth could be used as a feasible animal model to study neck metastasis of oral squamous cell carcinoma.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/00029330-200810010-00007</identifier><identifier>PMID: 19080119</identifier><language>eng</language><publisher>China: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing 100081,China%Department of Pathology, School of Basic Medical Sciences,Lanzhou University, Lanzhou, Gansu 730000, China</publisher><subject>Animals ; Carcinoma, Squamous Cell - pathology ; Cell Line, Tumor ; Humans ; Lymphatic Metastasis ; Mice ; Mice, Inbred BALB C ; Mouth Neoplasms - pathology ; Neck ; 动物模型 ; 口腔肿瘤 ; 淋巴节转移 ; 鳞状细胞癌</subject><ispartof>Chinese medical journal, 2008-10, Vol.121 (19), p.1891-1895</ispartof><rights>Copyright © Wanfang Data Co. Ltd. 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A feasible approach for an animal model to study OSCC lymph node metastasis was established and biological behaviors of three oral squamous cell carcinoma cell lines were compared. Methods After implanting three kinds of cell lines （GDC185, Tca8113, Tca83） into three different anatomical sites in nude mice, namely the tongue, floor of the mouth, and axillary fossa, we observed the tumorigenicity and the metastatic capacity, which was confirmed by histopathology under a surgical microscope. Results The animal model injected with GDC185 cells into the floor of the mouth had the highest rate of neck lymph node metastasis （55.6%） and the cell lines had significantly different biological behaviors. 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A feasible approach for an animal model to study OSCC lymph node metastasis was established and biological behaviors of three oral squamous cell carcinoma cell lines were compared. Methods After implanting three kinds of cell lines （GDC185, Tca8113, Tca83） into three different anatomical sites in nude mice, namely the tongue, floor of the mouth, and axillary fossa, we observed the tumorigenicity and the metastatic capacity, which was confirmed by histopathology under a surgical microscope. Results The animal model injected with GDC185 cells into the floor of the mouth had the highest rate of neck lymph node metastasis （55.6%） and the cell lines had significantly different biological behaviors. 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source HEAL-Link subscriptions: Lippincott Williams & Wilkins
subjects Animals
Carcinoma, Squamous Cell - pathology
Cell Line, Tumor
Humans
Lymphatic Metastasis
Mice
Mice, Inbred BALB C
Mouth Neoplasms - pathology
Neck
动物模型
口腔肿瘤
淋巴节转移
鳞状细胞癌
title Establishment of cervical lymph node metastasis model of squamous cell carcinoma in the oral cavity in mice
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