Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide

Aarsenic trioxide （AT） has a long history of use in both traditional Chinese medicine and in modem medicine in asthma therapy. Recently, Yin et al＇ found that AT even at small doses reduced the airway inflammation of sensitized guinea pigs. However the mechanism underlying this is still largely unkn...

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Bibliographic Details
Published in:Chinese medical journal 2008-11, Vol.121 (22), p.2346-2349
Main Authors: Yao, Xin, He, Hai-yan, Yang, Yan, Dai, Shan-lin, Sun, Pei-li, Yin, Kai-sheng, Huang, Mao
Format: Article
Language:English
Subjects:
Animals
Arsenicals - pharmacology
Cell Line, Tumor
Chromatin Immunoprecipitation
GATA3 Transcription Factor - metabolism
Gene Expression - drug effects
Humans
Immunoprecipitation
Interleukin-13 - genetics
Interleukin-13 - metabolism
Mice
Oxides - pharmacology
Promoter Regions, Genetic - genetics
Protein Binding
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction - drug effects
T-Lymphocytes - drug effects
T-Lymphocytes - metabolism
呼吸道疾病
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Summary:Aarsenic trioxide （AT） has a long history of use in both traditional Chinese medicine and in modem medicine in asthma therapy. Recently, Yin et al＇ found that AT even at small doses reduced the airway inflammation of sensitized guinea pigs. However the mechanism underlying this is still largely unknown. Interleukin 13 （IL-13）, as one of the important TH2 cytokines, plays an important role in asthma pathogenesis through promoting eosinophilic inflammation,
ISSN:0366-6999
2542-5641
DOI:10.1097/00029330-200811020-00024