Maximizing benefit of drug-eluting stent by direct coronary stenting because of further reduction of inflammatory response

Coronary stents have been used as standard mechanical devices for percutaneous coronary intervention （PCI） in patients with coronary artery disease （CAD）.They provide vessel wall scaffolding and prevent early elastic recoil and restenosis, which are major limitations of balloon angioplasty. Conseque...

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Bibliographic Details
Published in:Chinese medical journal 2009-03, Vol.122 (6), p.732-735
Main Authors: Li, Jian-Jun, Gao, Run-Lin
Format: Article
Language:English
Subjects:
Angioplasty, Balloon, Coronary - instrumentation
Angioplasty, Balloon, Coronary - methods
Coronary Restenosis - immunology
Coronary Restenosis - prevention & control
Drug-Eluting Stents
内膜增生
冠心病
冠状动脉支架
炎症反应
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Summary:Coronary stents have been used as standard mechanical devices for percutaneous coronary intervention （PCI） in patients with coronary artery disease （CAD）.They provide vessel wall scaffolding and prevent early elastic recoil and restenosis, which are major limitations of balloon angioplasty. Consequently, coronary stenting has a higher successful rate of PCI and improves the clinical outcome of the patients with CAD. Because of the permanent nature of metallic stents, however, their presence on the intimal surface of a coronary artery poses a risk associated with the continuous interaction between the metal and the surrounding tissue. This can lead to long-term endothelial dysfunction or chronic inflammation and may result in many potential concerns such as in-stent neointimal hyperplasia and thrombogenesis7
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2009.06.026