Gastromegaly infiltrated with plasma cells： a new feature of organomegaly in patients with POEMS syndrome

• Published in: Chinese medical journal 2010-05, Vol.123 (10), p.1356-1358
• Main Authors: Xie, Wei-lin, Guan, Jian-long, Han, Xing-hai, Ma, Da-lie, Jin, Zhen-dong
• Format: Article
• Language: English
• Subjects: Aged; Anti-Inflammatory Agents - therapeutic use; Cyclophosphamide - therapeutic use; Female; gamma-Globulins - therapeutic use; Humans; Immunosuppressive Agents - therapeutic use; Methylprednisolone - therapeutic use; Plasma Cells - pathology; POEMS Syndrome - complications; POEMS Syndrome - diagnosis; POEMS Syndrome - drug therapy; POEMS Syndrome - pathology; 发病机制; 组成部分; 细胞浸润; 综合征; 肝肿大; 脾肿大
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2010.10.026

Organomegaly is a major component of POEMS syndrome （an acronym of polyneuropathy,organomegaly, endocrinopatfiy, M protein, and-skin changes）, which is a rare multisystem disorder of unknown pathogenesis, In patients with POEMS syndrome, the organs involved in organomegaly usually are the liver, spleen, and lymph nodes,a-4 Three studies have reported the frequencies of hepatomegaly as 25%, 68%, and 78%; of splenomegaly as 22%, 52%, and 35%;