Variants of tumor necrosis factor-induced protein 3 gene are associated with left ventricular hypertrophy in hypertensive patients

• Published in: Chinese medical journal 2011-05, Vol.124 (10), p.1498-1503
• Main Authors: Xue, Hao, Wang, Shu-Xia, Wang, Xiao-Jian, Xin, Ying, Wang, Hu, Song, Xiao-Dong, Sun, Kai, Wang, Yi-Bo, Hui, Ru-Tai
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cross-Sectional Studies; DNA-Binding Proteins; Echocardiography; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertension - genetics; Hypertrophy, Left Ventricular - genetics; Intracellular Signaling Peptides and Proteins - genetics; Male; Middle Aged; Nuclear Proteins - genetics; Phenotype; Polymorphism, Single Nucleotide - genetics; Tumor Necrosis Factor alpha-Induced Protein 3; 单核苷酸多态性; 变异; 基因位点; 左心室; 心肌肥厚; 肿瘤坏死因子; 诱导蛋白; 高血压患者
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.10.011

Background Tumor necrosis factor-induced protein 3 （TNFAIP3） gene has been shown important in cardiac remodeling. The aim of the present study was to investigate whether the variants of TNFAIP3 gene are associated with left ventricular hypertrophy （LVH） in hypertensive patients.Methods Four representatives of all the other single nucleotide polymorphisms （SNPs） in TNFAIP3 gene were tested for association with hypertrophy in two independent hypertensive populations （n=2120 and n=324）.Results We found that only the tag SNP （rs5029939） was consistently lower in the hypertensives with cardiac hypertrophy than in those without cardiac hypertrophy in the two study populations, indicating a protective effect on LVH （odds ratio （OR） （95% confidence interval （CI））0.58 （0.358-0.863）, P=0.035; OR （95% CI）=0.477 （0.225-0.815）, P〈0.05,respectively）. Multiple regression analyses confirmed that the patients with G allele of rs5029939 had less thickness in inter-ventricular septum, left ventricular posterior wall, relative wall thickness and left ventricular mass index than did those with CC allele in the hypertensive patients in both study populations （all P〈0.01）.Conclusion These findings indicate that the SNP （rs5029939） in the TNFAIP3 gene may serve as a novel protective genetic marker for the development of LVH in patients with hypertension