miRNA deregulation in multiple myeloma

Multiple myeloma （MM） is an incurable plasma cell malignancy and is the second most common hematological cancer. It is characterized by complex, recurrent genetic and epigenetic abnormalities. Recent publications have linked miRNAs, a novel class of gene regulators to cancer including MM. miRNAs are...

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Bibliographic Details
Published in:Chinese medical journal 2011-10, Vol.124 (19), p.3164-3169
Main Authors: Bi, Chong Lei, Chng, Wee Joo
Format: Article
Language:English
Subjects:
Humans
MicroRNAs - physiology
miRNA
Multiple Myeloma - genetics
基因表达
多发性骨髓瘤
恶性肿瘤
放松管制
监管机构
表观遗传
非编码RNA
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Summary:Multiple myeloma （MM） is an incurable plasma cell malignancy and is the second most common hematological cancer. It is characterized by complex, recurrent genetic and epigenetic abnormalities. Recent publications have linked miRNAs, a novel class of gene regulators to cancer including MM. miRNAs are about 20 nucleotide, single strand, non-coding RNAs that repress gene expression by mRNA degradation or translational repression. Aberrant miRNA expression profiles have been described in MM, and their functional roles in MM pathogenesis are being increasingly recognized. This review summarizes the current literature on the role of miRNAs in MM and offers perspectives on future research and utilization of miRNAs in MM management.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2011.19.037