Stem cell-based therapy for erectile dysfunction

• Published in: Chinese medical journal 2011-11, Vol.124 (22), p.3810-3815
• Main Authors: Wu, Jian-Hong, Xia, Shu-Jie
• Format: Article
• Language: English
• Subjects: Erectile Dysfunction - therapy; Humans; Male; Stem Cell Transplantation - methods; 再生医学; 勃起功能障碍; 基因治疗; 基础; 干细胞移植; 细胞治疗; 细胞类型; 自我更新
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.22.037

Objective To review the effect of stem cells in erectile dysfunction as well as their application to the therapy of erectile dysfunction. Data sources The data used in the present article were mainly from PubMed with relevant English articles published from 1974 to 2011. The search terms were ＂stem cells＂ and ＂erectile dysfunction＂. Study selection Articles regarding the role of stem cells in erectile dysfunction and their application to the therapy of erectile dysfunction were selected. Results Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Meanwhile, in preclinical experiments, therapeutic gene-modified stem cells have been approved to offer a novel strategy for cell therapy and gene therapy of erectile dysfunction. Conclusion The transplantation of stem cells has the potential to provide cell types capable of restoring normal function after injury or degradation inerectile dysfunction. However, a series of problems, such as the safety of stem cells transplantation, their application in cell therapy and gene therapy of erectile dysfunction need further investigation.