Predisposing factors, diagnosis, treatment and prognosis of cerebral venous thrombosis during pregnancy and postpartum： a case-control study

• Published in: Chinese medical journal 2011-12, Vol.124 (24), p.4198-4204
• Main Authors: Gao, Hui, Yang, Bao-Jun, Jin, Li-Ping, Jia, Xiao-Fang
• Format: Article
• Language: English
• Subjects: Adult; Anticoagulants - therapeutic use; Case-Control Studies; Female; Humans; Intracranial Thrombosis - diagnosis; Intracranial Thrombosis - drug therapy; Intracranial Thrombosis - pathology; Postpartum Period; Pregnancy; Retrospective Studies; Risk Factors; Venous Thrombosis - diagnosis; Venous Thrombosis - drug therapy; Venous Thrombosis - pathology; Young Adult; 后脑; 怀孕期间; 早期诊断; 治疗; 血栓形成; 诱发因素; 静脉血栓; 预后
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.2011.24.015

Keywords pregnancy; puerperium; cerebral venous thromboembolism; anticoagulant agents; thrombolysis Background Previous investigations have demonstrated a relatively low incidence of stroke among young women, though both pregnancy and delivery can substantially increase the risk. Cerebral venous thrombosis may manifest different characteristics during pregnancy and postpartum as a result of their specific physiological statuses. This study aimed to identify the clinical manifestations, diagnosis, treatment, and prognosis of cerebral venous thrombosis during pregnancy and postpartum. Methods We conducted a retrospective analysis of 22 patients with cerebral venous thrombosis who were assigned to either group A （during pregnancy） or group B （during postpartum）. The relevant risk factors, initiation and development of the disease, clinical presentations, diagnosis, treatment, and prognosis were compared between the two stages. Results Cerebral venous thrombosis occurred during both pregnancy and postpartum, but was more common postpartum. Patients in group A had a longer hospitalization period than those in group B. Confirmed predisposing factors in 85.7% of patients of group A were dehydration, infection, and underlying cerebrovascular disorders. No obvious predisposing factors were identified in group B. The most frequent symptom was headache, with epileptic seizures, hemiparalysis and aphasia being less frequent symptoms. Focal neurological symptoms （P=0.022） and cerebral infarction （P=0.014） occurred more frequently in group A than in group B. Anticoagulation therapy proved to be safe for cerebral venous thrombosis patients during puerperium, regardless of parenchymal hemorrhage. However, more attention should be paid to spontaneous in-site placental hemorrhage in pregnant patients. Both groups had similar prognoses （P=1.000）, with 36.3% patients suffering from consequential dysfunction or recurrent intracranial hypertension Delayed diagnosis was associated with a poorer prognosis. Conclusions Cerebral venous thrombosis manifests different clinical characteristics during pregnancy and postpartum, though both have a good prognosis. Early diagnosis and prompt anticoagulation therapy are essential.