Acute myocardial infarction after capecitabine treatment： not always vasospasm is responsible

Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil （5-FU） after absorbtion. Capecitabine and its active metabolite, 5-FU, have cardiotoxic effects with reported instances of acute coronary syndromes caused due to coronary vasospasm. However, these agents e...

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Bibliographic Details
Published in:Chinese medical journal 2012-09, Vol.125 (18), p.3349-3351
Main Authors: Güvenç, Tolga Sinan, Celiker, Emel, Ozcan, Kazim Serhan, Ilhan, Erkan, Eren, Mehmet
Format: Article
Language:English
Subjects:
5-FU
Capecitabine
Coronary Thrombosis - chemically induced
Coronary Vasospasm - chemically induced
Deoxycytidine - adverse effects
Deoxycytidine - analogs & derivatives
Deoxycytidine - therapeutic use
Female
Fluorouracil - adverse effects
Fluorouracil - analogs & derivatives
Fluorouracil - therapeutic use
Humans
Middle Aged
Myocardial Infarction - chemically induced
冠状动脉
心血管系统
急性冠脉综合征
急性心肌梗死
治疗
活性代谢产物
痉挛
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Summary:Capecitabine is an orally available chemotherapeutic agent that is converted to 5-fluorouracil （5-FU） after absorbtion. Capecitabine and its active metabolite, 5-FU, have cardiotoxic effects with reported instances of acute coronary syndromes caused due to coronary vasospasm. However, these agents exert toxic effects on cardiovascular system and beyond vasospasm provacation. We report a 46-year-old patient diagnosed as acute inferior infarction who is treated with capecitabine for 3 months due to metastatic breast carcinoma, in whom thrombotic coronary occlusion was observed in angiography. This case demonstrates that apart from vasospasm, coronary thrombosis could be observed after capecitabine treatment, with a possible direct effect of this drug.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2012.18.029