Gliosis after traumatic brain injury in conditional ephrinB2-knockout mice

Background In response to the injury of the central nervous system （CNS）, the astrocytes upregulate the expression of glial fibrillary acidic protein （GFAP）, which largely contributes to the reactive gliosis after brain injury. The regulatory mechanism of this process is still not clear. In this stu...

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Bibliographic Details
Published in:Chinese medical journal 2012-11, Vol.125 (21), p.3831-3835
Main Authors: Liu, Ling, Chen, Xiao-Lin, Yang, Jian-Kai, Ren, Ze-Guang, Wang, Shuo
Format: Article
Language:English
Subjects:
Animals
Atrophy
Brain - pathology
Brain Injuries - complications
Brain Injuries - pathology
Ephrin-B2 - deficiency
Ephrin-B2 - physiology
Glial Fibrillary Acidic Protein
Gliosis - etiology
Immunohistochemistry
Mice
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins - analysis
中枢神经系统
创伤性脑损伤
基因敲除
小鼠
星形胶质细胞
生后
胶质纤维酸性蛋白
配体
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Summary:Background In response to the injury of the central nervous system （CNS）, the astrocytes upregulate the expression of glial fibrillary acidic protein （GFAP）, which largely contributes to the reactive gliosis after brain injury. The regulatory mechanism of this process is still not clear. In this study, we aimed to compare the ephrin-B2 deficient mice with the wild type ones with regard to qliosis after traumatic brain injury
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.2012.21.016