Role of CXCL12/CXCR4 signaling axis in pancreatic cancer

Objective This review focuses on the state-of-the-art of CXCL12/CXCR4 signaling axis in pancreatic cancer and its role in tumor progression. Data sources Relevant articles published in English were identified by searching in Pubmed from 1997 to 2013, with keywords ＂CXCL12＂, ＂CXCR4＂ and ＂pancreatic c...

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Published in:Chinese medical journal 2013-09, Vol.126 (17), p.3371-3374
Main Authors: Wu, Peng-Fei, Lu, Zi-Peng, Cai, Bao-Bao, Tian, Lei, Zou, Chen, Jiang, Kui-Rong, Miao, Yi
Format: Article
Language:English
Subjects:
Chemokine CXCL12 - genetics
Chemokine CXCL12 - metabolism
CXCR4
Humans
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - metabolism
Receptors, CXCR4 - genetics
Receptors, CXCR4 - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
信号
恶性肿瘤
数据来源
文献检索
肿瘤细胞
胰腺癌
轴
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cited_by cdi_FETCH-LOGICAL-c503t-f5ad5ebc12d95fe8b27cc1f74372f0ff6547b943e3cee8bc47f7422ae1a40de93
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container_issue 17
container_start_page 3371
container_title Chinese medical journal
container_volume 126
creator Wu, Peng-Fei
Lu, Zi-Peng
Cai, Bao-Bao
Tian, Lei
Zou, Chen
Jiang, Kui-Rong
Miao, Yi
description Objective This review focuses on the state-of-the-art of CXCL12/CXCR4 signaling axis in pancreatic cancer and its role in tumor progression. Data sources Relevant articles published in English were identified by searching in Pubmed from 1997 to 2013, with keywords ＂CXCL12＂, ＂CXCR4＂ and ＂pancreatic cancer＂. Important references from selected articles were also retrieved. Study selection Articles about CXCL12/CXCR4 signaling axis in pancreatic cancer and relevant mechanisms were selected. Results Pancreatic cancer has been one of the most lethal human malignancies, with median survival less than one year and overall 5-year survival only 6%. Tumor cells from pancreatic cancer express high level of CXCR4. CXCL12, the ligand for CXCR4, is extensively secreted by neighboring stromal cells and other distant organs. CXCL12 primarily binds to CXCR4, induces intracellular signaling through several divergent pathways, which are involved in progression and metastasis of pancreatic cancer. Conclusions CXCL12/CXCR4 signaling axis may play an important role in the communication between pancreatic cancer cells and their microenvironment, which may have effect on tumor proliferation, invasion, angiogenesis, metastasis and chemoresistance. CXCL12/CXCR4 signaling axis may serves as a novel therapeutic target for pancreatic cancer.
doi_str_mv 10.3760/cma.j.issn.0366-6999.20130748
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Data sources Relevant articles published in English were identified by searching in Pubmed from 1997 to 2013, with keywords ＂CXCL12＂, ＂CXCR4＂ and ＂pancreatic cancer＂. Important references from selected articles were also retrieved. Study selection Articles about CXCL12/CXCR4 signaling axis in pancreatic cancer and relevant mechanisms were selected. Results Pancreatic cancer has been one of the most lethal human malignancies, with median survival less than one year and overall 5-year survival only 6%. Tumor cells from pancreatic cancer express high level of CXCR4. CXCL12, the ligand for CXCR4, is extensively secreted by neighboring stromal cells and other distant organs. CXCL12 primarily binds to CXCR4, induces intracellular signaling through several divergent pathways, which are involved in progression and metastasis of pancreatic cancer. Conclusions CXCL12/CXCR4 signaling axis may play an important role in the communication between pancreatic cancer cells and their microenvironment, which may have effect on tumor proliferation, invasion, angiogenesis, metastasis and chemoresistance. CXCL12/CXCR4 signaling axis may serves as a novel therapeutic target for pancreatic cancer.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.20130748</identifier><identifier>PMID: 24033967</identifier><language>eng</language><publisher>China: Department of General Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, China</publisher><subject>Chemokine CXCL12 - genetics ; Chemokine CXCL12 - metabolism ; CXCR4 ; Humans ; Pancreatic Neoplasms - genetics ; Pancreatic Neoplasms - metabolism ; Receptors, CXCR4 - genetics ; Receptors, CXCR4 - metabolism ; Signal Transduction - genetics ; Signal Transduction - physiology ; 信号 ; 恶性肿瘤 ; 数据来源 ; 文献检索 ; 肿瘤细胞 ; 胰腺癌 ; 轴</subject><ispartof>Chinese medical journal, 2013-09, Vol.126 (17), p.3371-3374</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-f5ad5ebc12d95fe8b27cc1f74372f0ff6547b943e3cee8bc47f7422ae1a40de93</citedby><cites>FETCH-LOGICAL-c503t-f5ad5ebc12d95fe8b27cc1f74372f0ff6547b943e3cee8bc47f7422ae1a40de93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24033967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Peng-Fei</creatorcontrib><creatorcontrib>Lu, Zi-Peng</creatorcontrib><creatorcontrib>Cai, Bao-Bao</creatorcontrib><creatorcontrib>Tian, Lei</creatorcontrib><creatorcontrib>Zou, Chen</creatorcontrib><creatorcontrib>Jiang, Kui-Rong</creatorcontrib><creatorcontrib>Miao, Yi</creatorcontrib><title>Role of CXCL12/CXCR4 signaling axis in pancreatic cancer</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Objective This review focuses on the state-of-the-art of CXCL12/CXCR4 signaling axis in pancreatic cancer and its role in tumor progression. Data sources Relevant articles published in English were identified by searching in Pubmed from 1997 to 2013, with keywords ＂CXCL12＂, ＂CXCR4＂ and ＂pancreatic cancer＂. Important references from selected articles were also retrieved. Study selection Articles about CXCL12/CXCR4 signaling axis in pancreatic cancer and relevant mechanisms were selected. Results Pancreatic cancer has been one of the most lethal human malignancies, with median survival less than one year and overall 5-year survival only 6%. Tumor cells from pancreatic cancer express high level of CXCR4. CXCL12, the ligand for CXCR4, is extensively secreted by neighboring stromal cells and other distant organs. CXCL12 primarily binds to CXCR4, induces intracellular signaling through several divergent pathways, which are involved in progression and metastasis of pancreatic cancer. Conclusions CXCL12/CXCR4 signaling axis may play an important role in the communication between pancreatic cancer cells and their microenvironment, which may have effect on tumor proliferation, invasion, angiogenesis, metastasis and chemoresistance. CXCL12/CXCR4 signaling axis may serves as a novel therapeutic target for pancreatic cancer.</description><subject>Chemokine CXCL12 - genetics</subject><subject>Chemokine CXCL12 - metabolism</subject><subject>CXCR4</subject><subject>Humans</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Receptors, CXCR4 - genetics</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><subject>信号</subject><subject>恶性肿瘤</subject><subject>数据来源</subject><subject>文献检索</subject><subject>肿瘤细胞</subject><subject>胰腺癌</subject><subject>轴</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNo9kElLw0AUgAdRbK3-BYkHxUvS2ac5eJDgBgWhKHgbJpOZNiGZtJkGl1_vhC6n9-B9b_sAuEUwIYLDqW5UUiWl9y6BhPOYp2maYIgIFHR2AsaYURwzTtEpGB-BEbjwvoIQMyb4ORhhCglJuRiD2aKtTdTaKPvK5ghPQ1jQyJdLp-rSLSP1U_qodNFaOd0ZtS11pENquktwZlXtzdU-TsDn89NH9hrP31_essd5rBkk29gyVTCTa4SLlFkzy7HQGllBicAWWssZFXlKiSHahKqmItQwVgYpCguTkgm42839Vs4qt5RV23fhOC__Vrqphs-RgAQH8H4Hrrt20xu_lU3ptalr5Uzbe4koIZjTICCgDztUd633nbFy3ZWN6n4lgnKwLINlWcnBshwkykGiPFgO_df7VX3emOLYfdAagJv9glXrlpsg8shQAQUXMCX_nlqEzQ</recordid><startdate>20130905</startdate><enddate>20130905</enddate><creator>Wu, Peng-Fei</creator><creator>Lu, Zi-Peng</creator><creator>Cai, Bao-Bao</creator><creator>Tian, Lei</creator><creator>Zou, Chen</creator><creator>Jiang, Kui-Rong</creator><creator>Miao, Yi</creator><general>Department of General Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20130905</creationdate><title>Role of CXCL12/CXCR4 signaling axis in pancreatic cancer</title><author>Wu, Peng-Fei ; Lu, Zi-Peng ; Cai, Bao-Bao ; Tian, Lei ; Zou, Chen ; Jiang, Kui-Rong ; Miao, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-f5ad5ebc12d95fe8b27cc1f74372f0ff6547b943e3cee8bc47f7422ae1a40de93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Chemokine CXCL12 - genetics</topic><topic>Chemokine CXCL12 - metabolism</topic><topic>CXCR4</topic><topic>Humans</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Receptors, CXCR4 - genetics</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - physiology</topic><topic>信号</topic><topic>恶性肿瘤</topic><topic>数据来源</topic><topic>文献检索</topic><topic>肿瘤细胞</topic><topic>胰腺癌</topic><topic>轴</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Peng-Fei</creatorcontrib><creatorcontrib>Lu, Zi-Peng</creatorcontrib><creatorcontrib>Cai, Bao-Bao</creatorcontrib><creatorcontrib>Tian, Lei</creatorcontrib><creatorcontrib>Zou, Chen</creatorcontrib><creatorcontrib>Jiang, Kui-Rong</creatorcontrib><creatorcontrib>Miao, Yi</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Peng-Fei</au><au>Lu, Zi-Peng</au><au>Cai, Bao-Bao</au><au>Tian, Lei</au><au>Zou, Chen</au><au>Jiang, Kui-Rong</au><au>Miao, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of CXCL12/CXCR4 signaling axis in pancreatic cancer</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2013-09-05</date><risdate>2013</risdate><volume>126</volume><issue>17</issue><spage>3371</spage><epage>3374</epage><pages>3371-3374</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Objective This review focuses on the state-of-the-art of CXCL12/CXCR4 signaling axis in pancreatic cancer and its role in tumor progression. Data sources Relevant articles published in English were identified by searching in Pubmed from 1997 to 2013, with keywords ＂CXCL12＂, ＂CXCR4＂ and ＂pancreatic cancer＂. Important references from selected articles were also retrieved. Study selection Articles about CXCL12/CXCR4 signaling axis in pancreatic cancer and relevant mechanisms were selected. Results Pancreatic cancer has been one of the most lethal human malignancies, with median survival less than one year and overall 5-year survival only 6%. Tumor cells from pancreatic cancer express high level of CXCR4. CXCL12, the ligand for CXCR4, is extensively secreted by neighboring stromal cells and other distant organs. CXCL12 primarily binds to CXCR4, induces intracellular signaling through several divergent pathways, which are involved in progression and metastasis of pancreatic cancer. Conclusions CXCL12/CXCR4 signaling axis may play an important role in the communication between pancreatic cancer cells and their microenvironment, which may have effect on tumor proliferation, invasion, angiogenesis, metastasis and chemoresistance. CXCL12/CXCR4 signaling axis may serves as a novel therapeutic target for pancreatic cancer.</abstract><cop>China</cop><pub>Department of General Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, China</pub><pmid>24033967</pmid><doi>10.3760/cma.j.issn.0366-6999.20130748</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0366-6999
ispartof Chinese medical journal, 2013-09, Vol.126 (17), p.3371-3374
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source HEAL-Link subscriptions: Lippincott Williams & Wilkins
subjects Chemokine CXCL12 - genetics
Chemokine CXCL12 - metabolism
CXCR4
Humans
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - metabolism
Receptors, CXCR4 - genetics
Receptors, CXCR4 - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
信号
恶性肿瘤
数据来源
文献检索
肿瘤细胞
胰腺癌
轴
title Role of CXCL12/CXCR4 signaling axis in pancreatic cancer
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