Farnesoid X receptor in the study of fibrosis and its treatments

In the pathogenesis of various organs,fibrosis is often considered as a hardly irreversible progress,treatment of which has already become one of the most important prognostic indicators.Different mechanisms and many factors are involved in the process of organ fibrosis.With the development of relat...

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Bibliographic Details
Published in:Chinese medical journal 2013, Vol.126 (19), p.3775-3781
Main Authors: Zhao, Cong, Cong, Yu-ling, Xu, Yi-jun, Yin, Yan-ru
Format: Article
Language:English
Subjects:
Animals
Cholestasis - complications
Fibrosis - etiology
Gallbladder - pathology
Humans
Kidney - pathology
Lipid Metabolism
Liver Cirrhosis - etiology
Liver Cirrhosis - therapy
Myocardium - pathology
Receptors, Cytoplasmic and Nuclear - physiology
发病机制
受体
器官
治疗
法呢醇
法尼醇
激动剂
肝纤维化
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Summary:In the pathogenesis of various organs,fibrosis is often considered as a hardly irreversible progress,treatment of which has already become one of the most important prognostic indicators.Different mechanisms and many factors are involved in the process of organ fibrosis.With the development of relative researches,it is discovered that farnesoid X receptor （FXR;NR1H4） may play a significant role in this process.In addition,synthetic FXR agonists may make it possible for FXR to be the potential therapeutic target in curing fibrosis of organs.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20130774