Effects of low doses of aerosolized iloprost combined with tadalafil in treatment of adult congenital heart disease with severe pulmonary arterial hypertension

Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to...

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Bibliographic Details
Published in:Chinese medical journal 2014, Vol.127 (5), p.975-977
Main Authors: Zhang, Caojin, Huang, Yigao, Huang, Tao, Xia, Chunli, Huang, Xinsheng, Zhang, Guolin, Chen, Jimei, Chen, Jiyan, Zhuang, Jian
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Carbolines - administration & dosage
Carbolines - therapeutic use
Female
Heart Defects, Congenital - drug therapy
Humans
Hypertension, Pulmonary - drug therapy
Iloprost - administration & dosage
Iloprost - therapeutic use
Male
Tadalafil
Young Adult
低剂量
先天性
内皮素受体拮抗剂
心脏疾病
成人
肺动脉高压
雾化
靶向治疗
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Summary:Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to CHD.1,2 But whether the combination of targeted PAH therapy drugs provides similar synergistic effects is still controversial.1,2 Therefore,we investigated whether adult patients with severe PAH secondary to CHD would benefit from iloprost combined with low-dose tadalafil.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20132440