Effects of low doses of aerosolized iloprost combined with tadalafil in treatment of adult congenital heart disease with severe pulmonary arterial hypertension

Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to...

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Published in:Chinese medical journal 2014, Vol.127 (5), p.975-977
Main Authors: Zhang, Caojin, Huang, Yigao, Huang, Tao, Xia, Chunli, Huang, Xinsheng, Zhang, Guolin, Chen, Jimei, Chen, Jiyan, Zhuang, Jian
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
Carbolines - administration & dosage
Carbolines - therapeutic use
Female
Heart Defects, Congenital - drug therapy
Humans
Hypertension, Pulmonary - drug therapy
Iloprost - administration & dosage
Iloprost - therapeutic use
Male
Tadalafil
Young Adult
低剂量
先天性
内皮素受体拮抗剂
心脏疾病
成人
肺动脉高压
雾化
靶向治疗
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cited_by cdi_FETCH-LOGICAL-c437t-1878427ea9c8e960ebad2b2e0ab8b5efc07d2a909bf8fd669c101c1ae1e82ed03
cites cdi_FETCH-LOGICAL-c437t-1878427ea9c8e960ebad2b2e0ab8b5efc07d2a909bf8fd669c101c1ae1e82ed03
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container_issue 5
container_start_page 975
container_title Chinese medical journal
container_volume 127
creator Zhang, Caojin
Huang, Yigao
Huang, Tao
Xia, Chunli
Huang, Xinsheng
Zhang, Guolin
Chen, Jimei
Chen, Jiyan
Zhuang, Jian
description Pulmonary arterial hypertension （PAH） is a common and serious complication of congenital heart disease （CHD）.Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase （PDE-5） inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to CHD.1,2 But whether the combination of targeted PAH therapy drugs provides similar synergistic effects is still controversial.1,2 Therefore,we investigated whether adult patients with severe PAH secondary to CHD would benefit from iloprost combined with low-dose tadalafil.
doi_str_mv 10.3760/cma.j.issn.0366-6999.20132440
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identifier ISSN: 0366-6999
ispartof Chinese medical journal, 2014, Vol.127 (5), p.975-977
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source LWW_医学期刊
subjects Administration, Inhalation
Adult
Carbolines - administration & dosage
Carbolines - therapeutic use
Female
Heart Defects, Congenital - drug therapy
Humans
Hypertension, Pulmonary - drug therapy
Iloprost - administration & dosage
Iloprost - therapeutic use
Male
Tadalafil
Young Adult
低剂量
先天性
内皮素受体拮抗剂
心脏疾病
成人
肺动脉高压
雾化
靶向治疗
title Effects of low doses of aerosolized iloprost combined with tadalafil in treatment of adult congenital heart disease with severe pulmonary arterial hypertension
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