Perioperative outcomes of laparoscopic versus open splenectomy for nontraumatic diseases： a meta-analysis

Background Surgical treatment has become the standard treatment for nontreumatic diseases of the spleen.This metaanalysis compared the relative merits of laparoscopic splenectomy （LS） with open splenectomy （OS） for nontraumatic splenic diseases.Methods A literature search was performed to identify s...

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Bibliographic Details
Published in:Chinese medical journal 2014, Vol.127 (13), p.2504-2510
Main Authors: Chen, Jiang, Ma, Rui, Yang, Shouzhang, Lin, Shuang, He, Shilin, Cai, Xiujun
Format: Article
Language:English
Subjects:
Humans
Laparoscopy - adverse effects
Laparoscopy - methods
Spleen - surgery
Splenectomy - adverse effects
Splenectomy - methods
Splenic Diseases - surgery
创伤性
围手术期
大规模杀伤性武器
操作系统
疾病
脾
腹腔镜
随机效应模型
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Summary:Background Surgical treatment has become the standard treatment for nontreumatic diseases of the spleen.This metaanalysis compared the relative merits of laparoscopic splenectomy （LS） with open splenectomy （OS） for nontraumatic splenic diseases.Methods A literature search was performed to identify studies comparing perioperative outcomes in patients who underwent LS or OS for nontraumatic diseases.Pooled odds ratios （ORs） and weighted mean differences （WMD） with 95％ confidence intervals （C/s） were calculated using a fixed-or random-effects model.Results Thirty-five studies matched the selection criteria.Of the 7 269 patients included 3 981 underwent LS and 3 288 underwent OS for nontraumatic diseases.OS was associated with shorter operation time （WMD=42.65,95％ CI：25.58-59.73）,whereas LS was associated with reduced operative blood loss （WMD=-133.95,95％ CI：-229.02 to-38.88）,need for blood transfusion requirement （OR=0.53,95％ CI：0.39-0.72）,overall postoperative morbidity rate （OR=0.44,95％ CI：0.38-0.51）,postoperative mortality rate （OR=0.38,95％ CI：0.24-0.59）,and length of hospital stay （WMD =-2.73,95％CI：-3.34 to-2.12）.Conclusions LS is superior to OS for nontraumatic diseases,with reduced operative blood loss,need for blood transfusion,postoperative morbidity and mortality rates,and length of hospital stay,although OS is associated with reduced operation time.LS may be a good alternative to OS for patients with nontraumatic splenic diseases.
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20132560