Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus

Background Novel influenza A viruses of avian-origin may be the precursors of pandemic strains.This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases.Methods Collecting clinical data of three cases of human infection...

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Bibliographic Details
Published in:中华医学杂志（英文版） 2014-09, Vol.127 (18), p.3238-3242
Main Authors: Zhang Wei, Wan Jianguo, Qian Kejian, Liu Xiaoqing, Xiao Zuke, Sun Jian, Zeng Zhenguo
Format: Article
Language:English
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Summary:Background Novel influenza A viruses of avian-origin may be the precursors of pandemic strains.This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases.Methods Collecting clinical data of three cases of human infection with a novel reassortment avian influenza A (H10N8)virus in Nanchang,Jiangxi Province,China.Results Three cases of human infection with a new reassortment avian influenza A(H10N8) virus were described,of which two were fatal cases,and one was severe case.These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure.Conclusion This novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections,and should be added to concerns in clinical practice.
ISSN:0366-6999
DOI:10.3760/cma.j.issn.0366-6999.20140994