Comparison of ocular modulation transfer function determined by a ray-tracing aberrometer and a double-pass system in early cataract patients

• Published in: Chinese medical journal 2014, Vol.127 (19), p.3454-3458
• Main Authors: Qiao, Liya, Wan, Xiuhua, Cai, Xiaogu, Vasudevan, Balamurali, Xiong, Ying, Tan, Jiaxuan, Guan, Zheng, Atchison, David A, Wang, Ningli
• Format: Article
• Language: English
• Subjects: Aberrometry - methods; Adult; Aged; Cataract - physiopathology; Female; Humans; Male; Middle Aged; Visual Acuity - physiology; 光线追踪; 双通道系统; 多元逐步回归分析; 早期; 波前像差; 白内障; 眼部; 调制传递函数
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20141492

Background The evaluation of retinal image quality in cataract eyes has gained importance and the clinical modulation transfer functions （MTF） can obtained by aberrometer and double pass （DP） system. This study aimed to compare MTF derived from a ray tracing aberrometer and a DP system in early cataractous and normal eyes. Methods There were 128 subjects with 61 control eyes and 67 eyes with early cataract defined according to the Lens Opacities Classification System II1. A laser ray-tracing wavefront aberrometer （iTrace） and a double pass （DP） system （OQAS） assessed ocular MTF for 6.0 mm pupil diameters following dilation. Areas under the MTF （AUMTF） and their correlations were analyzed. Stepwise multiple regression analysis assessed factors affecting the differences between iTrace- and OQAS-derived AUMTF for the early cataract group. Results For both early cataract and control groups, iTrace-derived MTFs were higher than OQAS-derived MTFs across a range of spatial frequencies （P 〈0.01）. No significant difference between the two groups occurred for iTrace-derived AUMTF, but the early cataract group had significantly smaller OQAS-derived AUMTF than did the control group （P 〈0.01）. AUMTF determined from both the techniques demonstrated significant correlations with nuclear opacities, higher-order aberrations （HOAs）, visual acuity, and contrast sensitivity functions, while the OQAS-derived AUMTF also demonstrated significant correlations with age and cortical opacity grade. The factors significantly affecting the difference between iTrace and OQAS AUMTF were root-mean-squared HOAs （standardized beta coefficient=-0.63, P 〈0.01） and age （standardized beta coefficient=0.26, P 〈0.01）. Conclusions MTFs determined from a iTrace and a DP system （OQAS） differ significantly in early cataractous and normal subjects. Correlations with visual performance were higher for the DP system. OQAS-derived MTF may be useful as an indicator of visual performance in early cataract eyes.